TranscriptionTumorLaboratory2019

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The Transcription and Tumor Laboratory
Publications:

TFIIIC binding to Alu elements controls gene expression via chromatin looping and histone acetylation.

Roberto Ferrari, Lara Isabel de Llobet Cucalon, Chiara Di Vona, François Le Dilly, Enrique Vidal, Antonios Lioutas, Javier Quilez Oliete, Laura Jochem, Erin Cutts, Giorgio Dieci, Alessandro Vannini, Martin Teichmann,  Susana de la Luna, Miguel Beato.

doi: https://doi.org/10.1101/455733

https://www.biorxiv.org/content/10.1101/455733v3

Accepted for publication in Molecular Cell

The hRPC62 subunit of human RNA polymerase III displays helicase activity. Leyla El Ayoubi, Hélène Dumay-Odelot, Aleksandar Chernev, Fanny Boissier, Lionel Minvielle-Sébastia, Henning Urlaub, Sébastien Fribourg, and Martin Teichmann. 2019. Nucleic Acids Research.

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz788/5569986?searchresult=1

Delespaul, L., Merle , C., Lesluyes, T., Lagarde, P., Le Guellec, S., Pérot, G., Baud, J., Prochazkova-Carlotti, M.,  Danet, C., Fèvre, M., Rousseau, B., Durrieu-Gaillard, S., Teichmann, M., Coindre, J.M., Lartigue, L. and Chibon, F. (2019). Fusion-mediated genomic instability promotes aneuploidy patterns that resemble human tumors. Oncogene. Jul 3. doi: 10.1038/s41388-019-0859-6. [Epub ahead of print]

https://www.nature.com/articles/s41388-019-0859-6

Karine Choquet, K., Forget, D., Meloche, E., Dicaire, MJ., Bernard, G., Vanderver, A., Schiffmann, R., Fabian, M., Teichmann, M., Coulombe, B., Brais, B., and Kleinman, C. (2019). Leukodystrophy-associated POLR3A mutations down-regulate the RNA polymerase III transcript and important regulatory RNA BC200. J. Biol. Chem. Mar 21. pii: jbc.RA118.006271. doi: 10.1074/jbc.RA118.006271.

 

Cullot, G., Boutin, J., Toutain, J., Prat, F., Pennamen, P., Rooryck, C., Teichmann, M., Rousseau, E., Lamrissi-Garcia, I., Guyonnet-Duperat, V., Bibeyran, A., Lalanne, M.,  Prouzet-Mauléon, V., Turcq, B., Ged, C., Blouin, JM., Richard, E., Dabernat, S., Moreau-Gaudry, F., and Bedel, A. (2019). CRISPR/Cas9 genome editing induces megabase-scale chromosomal truncations. Nat. Commun. Mar 8. https://doi.org/10.1038/s41467-019-09006-2

 

Petrie, J., Swan, C., Ingram, R., Frame, F., Collins, A., Dumay-Odelot, H., Teichmann, M., Maitland, N., and White, RJ. (2019).  Selective effects on prostate cancer cells of targeting RNA polymerase III.  Nucleic Acids Res. Mar 1. pii: gkz128. doi: 10.1093/nar/gkz128. [Epub ahead of print]

 

Dorboz, I., Dumay-Odelot, H., Boussaid, K., Bouyacoub, Y., Barreau, P.,  Samaan, S., Jmel, H., Eymard-Pierre, E., Cances, C., Bar, C., Desportes, V., Peretti, N., Renaldo, F., Elmaleh, M., Teichmann, M, and Boespflug-Tanguy, O. (2018). Mutation in POLR3K cause hypomyelinating leukodystrophy and abnormal ribosomal RNA regulation. Neurology Genetics. 4(6):e289. doi: 10.1212/NXG.0000000000000289. eCollection 2018 Dec.

 

Durrieu-Gaillard S, Dumay-Odelot H, Boldina G, Tourasse NJ, Allard D, André F, Macari F, Choquet A, Lagarde P, Drutel G, Leste-Lasserre T, Petitet M, Lesluyes T, Lartigue-Faustin L, Dupuy JW, Chibon F, Roeder RG, Joubert D, Vagner S, Teichmann M. (2018). Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.

Cell Cycle. 17(5):605-615. doi: 10.1080/15384101.2017.1405881. Epub 2018 Jan 22.

 

Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B. (2017). Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation. Mol Brain. 10(1):13. doi: 10.1186/s13041-017-0294-y.

 

Le Saux G, Plawinski L, Parrot C, Nlate S, Servant L, Teichmann M, Buffeteau T, Durrieu MC. (2016). Surface bound VEGF mimicking peptide maintains endothelial cell proliferation in the absence of soluble VEGF In Vitro. J Biomed Mater Res A. 104(6):1425-36. doi: 10.1002/jbm.a.35677. Epub 2016 Feb 19.

 

Agarwal, P., Enroth, S., Teichmann, M., Wiklund, H.J., Smit, A., Westermark, B. and Singh, U. (2016). Growth signals employ CGGBP1 to suppress transcription of Alu-SINEs. Cell Cycle. 15(12):1558-71. doi: 10.4161/15384101.2014.967094.

Boissier, F., Dumay-Odelot, H., Teichmann, M. and Fribourg, S. (2015). Structural analysis of human RPC32β-RPC62 complex. J Struct Biol, 192(3):313-9. doi: 10.1016/j.jsb.2015.09.004. Epub 2015 Sep 21.

 

Macari, F., El-houfi, Y., Boldina, G., Bystöm, A., Khoury-Hanna, S., Ollier, J., Yazdani, L., Zheng, G.,  Bièche, I., Legrand, N., Paulet, D., Durrieu-Gaillard, S., Delbecq, S., Lapeyre, B., Bauchet, L., Pannequin, J., Hollande, F., Pan, T., Teichmann, M., Vagner, S., David, A., Choquet, A. and Joubert, D. (2015) TRM6/61 connects PKCα with translational control: impact on tRNAiMet oncogenic properties. Oncogene. 35(14):1785-96.doi: 10.1038/onc.2015.244.

 

Byambajav Buyandelger, B., Kostin, S., Vouffo, J., Gunkel, S., McSweeney, S., Perrot, A., Pfeiffer, C., Reza Toliat, M., Ilieva, K., Krysztofinska, E., Schubert, C., Schmidt, A., Teucher, N., Schulze, F., Kube, D., Chen, J., Teichmann, M., Eilers, M., Haverkamp, W., von Ahsen, N., Barton, P., Höhne, W., Lara-Pezzi, E., Felkin, L.A., Schneider, M., Isaacson, R., Milting, H., Nürnberg, P. and Knöll, R. (2015). ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure. Circ Cardiovasc Genet. 8(5):643-52. doi: 10.1161/CIRCGENETICS.113.000690. Epub 2015 Jul 14.

 

Walz, S., Lorenzin, F., Morton, J., Wiese , K.E., von Eyss, B., Herold, S., Rycak, L., Dumay-Odelot, H., Karim , S., Bartkuhn, M., Roels, F., Wuestefeld, T., Fischer, M., Teichmann, M., Zender, L., Wei, C.-L., Sansom, O., Wolf, E., and Eilers, M. (2014). Activation and repression by oncogenic Myc shape tumour-specific gene expression profiles. Nature, 511(7510):483-7.

 

Dumay-Odelot, H., Durrieu-Gaillard, S., El Ayoubi, L., Parrot, C. and Teichmann, M. (2014). Contributions of in vitro transcription to the understanding of human RNA polymerase III transcription. Transcription 5(1):e27526. doi: 10.4161/trns.27526.

 

Pascali, C. and Teichmann, M. (2013) RNA polymerase III transcription - regulated by chromatin structure and regulator of nuclear chromatin organization. in " EPIGENETICS: DEVELOPMENT AND DISEASE". Subcell Biochem. Book chapter. Springer Press. 61:261-87.

 

Teichmann, M., Dumay-Odelot H, Fribourg S. (2012). Structural and functional aspects of winged-helix domains at the core of transcription initiation complexes. Transcription, 3(1):2-7. doi: 10.4161/trns.3.1.18917.

 

Tétreault, M., Choquet, K., Orcesi, S., Tonduti, D., Balottin, U., Teichmann, M., Fribourg, S., Schiffmann, R., Brais, B., Vanderver, A. and Bernard, G. (2011). Recessive Mutations in POLR3B, Encoding the Second Largest Subunit of Pol III, Cause a Rare Hypomyelinating Leukodystrophy. Am. J. Hum. Genet. 89(5), 652-655. [Epub ahead of print] Oct 27.

 

Bernard, G., Chouery, E., Putorti, M.L., Tétreault, M., Takanohashi, A., Carosso, G., Clément, I., Boespflug-Tanguy, O., Rodriguez, D., Delague, V., Abou Ghoch, J., Jalkh, N., Dorboz, I., Fribourg, S., Teichmann, M., Megarbane, A., Schiffmann, R., Vanderver, A. and Brais, B. (2011). Mutations of POLR3A Encoding a Catalytic Subunit of RNA Polymerase Pol III Cause a Recessive Hypomyelinating Leukodystrophy. Am. J. Hum. Genet. 89(3), 415-423. Aug 17.

 

Orioli, A., Pascali, C., Pagano, A., Teichmann, M. and Dieci, G. (2011). RNA polymerase III transcription control elements: themes and variations. Gene 493(2):185-94. doi: 10.1016/j.gene.2011.06.015. Epub 2011 Jun 25. Review.

 

Orioli, A., Pascali, C., Quartararo, J., Diebel, K.W., Praz, V., Romascano, D., Percudani, R., van Dyk, L.F., Hernandez, N., Teichmann, M. and Dieci, G. (2011). Widespread occurrence of non-canonical transcription termination by human RNA polymerase III. Nucleic Acids Research. 39, 5499-5512. Epub 2011 Mar 17.

 

Lefèvre S, Dumay-Odelot H, El-Ayoubi L, Budd A, Legrand P, Pinaud N, Teichmann M, Fribourg S. (2011). Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation. Nat Struct Mol Biol. 18(3):352-8.

 

Teichmann, M., Dieci, G., Pascali, C. and Boldina, G (2010). General transcription factors and subunits of RNA polymerase III: Paralogues for promoter- and cell type-specific transcription in multicellular eukaryotes. Transcription, 1 (3), 130-135.

 

Dumay-Odelot, H., Durrieu-Gaillard S., Da Silva D., Roeder R.G., Teichmann, M. (2010). Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Cell Cycle.  9 (18), 3687-3699. Epub 2010 Sep 1.

Haurie, V., Gaillard-Durrieu, S., Dumay-Odelot, H., Da Silva, D., Rey, C.,  Prochazkova, M., Roeder, R.G., Besser, D. and M. Teichmann (2010). Two forms of human RNA polymerase III with specific functions in cell growth and transformation. Proc. Natl. Acad. Sci. USA, 107(9):4176-81. [Epub ahead of print]

 

Pitulescu, M.E., Teichmann, M., Luo, L. and M. Kessel. (2009). TIPT and geminin interact with basal transcription factors to synergize in transcriptional regulation. BMC Biochem. 10: 16-31.

 

Woiwode, A., Johnson, S.A., Zhong, S., Zhang, C., Roeder, R.G., Teichmann, M. and Johnson D.L. (2008). PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex. Mol. Cell. Biol. 28 (12): 4204-4214.

 

Dieci, G., Fiorino, G., Castelnuovo, M., Teichmann, M. and A. Pagano. (2007) The expanding RNA polymerase III transcriptome. Trends Genet. 23 (12), 614-622.

 

Dumay-Odelot, H., Marck, C., Durrieu-Gaillard, S., Lefebvre, O., Jourdain, S., Prochazkova, M., Pflieger, A. and M. Teichmann (2007). Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. J. Biol. Chem. 282 (23): 17179-17189.

 

Chong, J.A., Moran, M.M., Teichmann, M.‍,‍‍‍‍‍‍‍‍ Kaczmarek, J.S., Roeder, R.G. and D.E. Clapham (2005). TLF is a Functional Regulator of Transcription: Reciprocal regulation of the Neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. Mol. Cell. Biol., 25 (7): 2632-2643.

 

Weser, S., Gruber, C., Haffner, H.M., Teichmann, M., Roeder, R.G., Seifart, K.H. and W. Meißner (2004). The 250 kDa form of HsBdp1 (TFNR) is an essential component of human TFIIIC1 activity. J. Biol. Chem. 279 (26): 27022-27029.

 

Leach, K., Vieira, K., Lee Kang, S.H., Aslanian, A., Teichmann, M., Roeder, R.G., and Bungert, J. (2003). Characterization of the human b-globin downstream promoter region. Nucleic Acids Research, 31 (4):1292-1301.

 

Purrello, M., Di Pietro, C., Rapisarda, A., Amico, V., Engel, H., Hsieh, Y.J., Teichman, M., Wang, Z., Sichel, G., Roeder, R.G. and K.H. Grzeschik (2001). Genes for human general transcription factors TFIIIB, TFIIIB-associated proteins, TFIIIC2, and PTF/SNAPc: positional candidates for tumor predisposition or inherited genetic diseases? Oncogene. 20 (35): 4877-4883.

 

Mertens, C., Hofmann, I., Wang, Z., Teichmann, M., Sepehri Chong, S., Schnölzer, M. and W. W. Franke (2001). Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2. Proc. Natl. Acad. Sci. USA., 98 (14):7795-7800.

 

Zhang, D., Penttila, T.L., Morris, P.L., Teichmann, M. and R.G. Roeder (2001). Spermiogenesis deficiency in mice lacking the trf2 gene. Science 292 (5519): 1153-1155.

 

Teichmann, M., Wang, Z. and R.G. Roeder (2000). A stable complex of a novel transcription factor IIB-related protein, TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements. Proc. Natl. Acad. Sci. USA. 97 (26): 14200-14205.

 

Teichmann, M., Wang, Z., Martinez, E., Tjernberg, A., Zhang, D., Vollmer, F., Chait, B.T. and R.G. Roeder (1999). Human TBP Related Factor 2 is stably associated with TFIIA in HeLa cells. Proc. Natl. Acad. Sci. USA. 96 (24): 13720-13725.

 

Kober, I., Teichmann, M. and K.H. Seifart (1998). hTFIIIB-b stably binds to pol II promoters and recruits RNA polymerase III in a hTFIIIC1 dependent way. J. Mol. Biol. 284 (1): 7-20.

 

Teichmann, M., Dieci, G., Huet, J., Rueth, J., Sentenac, A. and K.H. Seifart (1997). Functional interchangeability of TFIIIB components from yeast and human cells in vitro. EMBO J. 16 (15): 4708-4716.

 

Teichmann, M. and K.H. Seifart (1995). Physical separation of two different forms of human TFIIIB active in transcription of the U6 or the VAI gene in vitro. EMBO J. 14 (23): 5974-5983.

 

Waldschmidt, R., Jahn, D., Teichmann, M., Jahn, M., Meißner, W. and K.H. Seifart (1990). Physical and immunological characterization of human transcription factor IIIA. Eur. J. Biochem. 194 (1): 167-176.

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