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Transcription and Tumor Laboratory
Lab Members
Martin Teichmann
Director of the Doctoral School of
Life Sciences and Health
phone: ++33-5-5757-4647
Francis Sagliocco
Associate Professor
Coordinator of the Master of Cellular and Molecular Genetics
phone: ++33-5-5757-9504
Angélique Alonso-Marrau
phone: ++33-5-5757-9504
Elisabeth Lata
PhD student
phone: ++33-5-5757-9504
Pascale Sarkis
Master 2 student
phone: ++33-5-5757-9504
We are interested in dissecting mechanisms that are altered in transcription regulation by human RNA polymerase (Pol) III during the process of tumoral transformation and in stem cells. For that purpose, we employ genetically defined human cellular model systems. We are in addition interested in determining the roles of Pol III in the development of leukodystrophies.
Nous nous intéressons à la dissection des mécanismes altérés dans la régulation de la transcription par l'ARN polymérase (Pol) III humaine au cours du processus de transformation tumorale et dans les cellules souches. À cette fin, nous utilisons des systèmes modèles cellulaires avec des fonds génétiques bien définis. Nous sommes également intéressés à déterminer les rôles de la Pol III dans le développement des leucodystrophies.
Our Team members are participating in teaching modules of the bachelor degree and of the Masters of Genetics (GMC), Cellular Biology (BCPP), Cancer Biology and Biochemistry of the University of Bordeaux.
For more detailed information, please contact the laboratory.
Les membres de notre équipe participent aux modules d’enseignement de la Licence et des Master de l’Université de Bordeaux en génétique (GMC), en biologie cellulaire (BCPP), en biologie du cancer et en biochimie.
Pour plus d'informations, veuillez contacter le laboratoire.
Selected Publications

Upcoming in February 2021: Elisabeth Lata and Martin Teichmann; Your paper "Activation and repression at the heart of human RNA polymerase III" has now been scheduled for publication in Nature Structural & Molecular Biology on Feb 8 at 4PM GMT which is when the embargo will lift.


TFIIIC binding to Alu elements controls gene expression via chromatin looping and histone acetylation.

Ferrari R, de Llobet Cucalon LI, Di Vona C, Le Dilly F, Vidal E, Lioutas A, Oliete JQ, Jochem L, Cutts E, Dieci G, Vannini A, Teichmann M, de la Luna S, Beato M.

Mol Cell. 2019 Nov 20. pii: S1097-2765(19)30798-1. doi: 10.1016/j.molcel.2019.10.020. [Epub ahead of print]

The hRPC62 subunit of human RNA polymerase III displays helicase activity.

El Ayoubi L, Dumay-Odelot H, Chernev A, Boissier F, Minvielle-Sébastia L, Urlaub H, Fribourg S, Teichmann M.

Nucleic Acids Res. 2019 Sep 16. pii: gkz788. doi: 10.1093/nar/gkz788.


Fusion-mediated genomic instability promotes aneuploidy patterns that resemble human tumors.

Delespaul, L, Merle , C, Lesluyes, T, Lagarde, P, Le Guellec, S, Pérot, G, Baud, J, Prochazkova-Carlotti, M,  Danet, C, Fèvre, M, Rousseau, B, Durrieu-Gaillard, S, Teichmann, M, Coindre, JM, Lartigue, L, Chibon, F. Oncogene. 2019 Jul 3. doi: 10.1038/s41388-019-0859-6. [Epub ahead of print]


Leukodystrophy-associated POLR3A mutations down-regulate the RNA polymerase III transcript and important regulatory RNA BC200.

Karine Choquet, K, Forget, D, Meloche, E, Dicaire, MJ, Bernard, G, Vanderver, A, Schiffmann, R, Fabian, M, Teichmann, M, Coulombe, B, Brais, B, and Kleinman, C. J Biol Chem. 2019 May 3;294(18):7445-7459. doi: 10.1074/jbc.RA118.006271.

CRISPR/Cas9 genome editing induces megabase-scale chromosomal truncations.

Cullot, G, Boutin, J, Toutain, J, Prat, F, Pennamen, P, Rooryck, C, Teichmann, M, Rousseau, E, Lamrissi-Garcia, I, Guyonnet-Duperat, V, Bibeyran, A, Lalanne, M, Prouzet-Mauléon, V, Turcq, B, Ged, C, Blouin, JM, Richard, E, Dabernat, S, Moreau-Gaudry, F, Bedel, A.

Nat Commun. 2019 Mar 8;10(1):1136. doi: 10.1038/s41467-019-09006-2.

Effects on prostate cancer cells of targeting RNA polymerase III.
Petrie1, JL, Swan, C, Ingram, RM, Frame, FM, Collins, AT, Dumay-Odelot, H, Teichmann, M, Maitland, NJ, White, RJ.

Nucleic Acids Res. 2019 May 7;47(8):3937-3956. doi: 10.1093/nar/gkz128.

Mutation in POLR3K causes hypomyelinating leukodystrophy and abnormal ribosomal RNA regulation.

Dorboz I, Dumay-Odelot H, Boussaid K, Bouyacoub Y, Barreau P, Samaan S, Jmel H, Eymard-Pierre E, Cances C, Bar C, Poulat AL, Rousselle C, Renaldo F, Elmaleh-Bergès M, Teichmann M, Boespflug-Tanguy O.

Neurol Genet. 2018 Dec 3;4(6):e289.

Regulation of RNA polymerase III transcription during transformation of human IMR90 fibroblasts with defined genetic elements.

Durrieu-Gaillard S, Dumay-Odelot H, Boldina G, Tourasse NJ, Allard D, André F, Macari F, Choquet A, Lagarde P, Drutel G, Leste-Lasserre T, Petitet M, Lesluyes T, Lartigue-Faustin L, Dupuy JW, Chibon F, Roeder RG, Joubert D, Vagner S, Teichmann M.

Cell Cycle. 2018;17(5):605-615.

Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation.

Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B.

Mol Brain. 2017 Apr 13;10(1):13.

TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis.

Macari F, El-Houfi Y, Boldina G, Xu H, Khoury-Hanna S, Ollier J, Yazdani L, Zheng G, Bièche I, Legrand N, Paulet D, Durrieu S, Byström A, Delbecq S, Lapeyre B, Bauchet L, Pannequin J, Hollande F, Pan T, Teichmann M, Vagner S, David A, Choquet A, Joubert D.

Oncogene. 2016 Apr 7;35(14):1785-96.

Structural analysis of human RPC32β-RPC62 complex.

Boissier F, Dumay-Odelot H, Teichmann M, Fribourg S.

J Struct Biol. 2015 Dec;192(3):313-319.


Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wüstefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E, Eilers M.

Nature. 2014 Jul 24;511(7510):483-7.

Contributions of in vitro transcription to the understanding of human RNA polymerase III transcription.

Dumay-Odelot H, Durrieu-Gaillard S, El Ayoubi L, Parrot C, Teichmann M.

Transcription. 2014;5(1):e27526.

RNA polymerase III transcription - regulated by chromatin structure and regulator of nuclear chromatin organization.

Pascali C, Teichmann M.

Subcell Biochem. 2013;61:261-87.

Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy.

Tétreault M, Choquet K, Orcesi S, Tonduti D, Balottin U, Teichmann M, Fribourg S, Schiffmann R, Brais B, Vanderver A, Bernard G.

Am J Hum Genet. 2011 Nov 11;89(5):652-5.

Mutations of POLR3A encoding a catalytic subunit of RNA polymerase Pol III cause a recessive hypomyelinating leukodystrophy.

Bernard G, Chouery E, Putorti ML, Tétreault M, Takanohashi A, Carosso G, Clément I, Boespflug-Tanguy O, Rodriguez D, Delague V, Abou Ghoch J, Jalkh N, Dorboz I, Fribourg S, Teichmann M, Megarbane A, Schiffmann R, Vanderver A, Brais B.

Am J Hum Genet. 2011 Sep 9;89(3):415-23.

Widespread occurrence of non-canonical transcription termination by human RNA polymerase III.

Orioli A, Pascali C, Quartararo J, Diebel KW, Praz V, Romascano D, Percudani R, van Dyk LF, Hernandez N, Teichmann M, Dieci G.

Nucleic Acids Res. 2011 Jul;39(13):5499-512.

Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation.

Lefèvre S, Dumay-Odelot H, El-Ayoubi L, Budd A, Legrand P, Pinaud N, Teichmann M, Fribourg S.

Nat Struct Mol Biol. 2011 Mar;18(3):352-8.

General transcription factors and subunits of RNA polymerase III: Paralogs for promoter- and cell type-specific transcription in multicellular eukaryotes.

Teichmann M, Dieci G, Pascali C, Boldina G.

Transcription. 2010 Nov;1(3):130-135.

Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.

Dumay-Odelot H, Durrieu-Gaillard S, Da Silva D, Roeder RG, Teichmann M.

Cell Cycle. 2010 Sep 15;9(18):3687-99.

Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.

Haurie V, Durrieu-Gaillard S, Dumay-Odelot H, Da Silva D, Rey C, Prochazkova M, Roeder RG, Besser D, Teichmann M.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4176-81.

PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.

Woiwode A, Johnson SA, Zhong S, Zhang C, Roeder RG, Teichmann M, Johnson DL.

Mol Cell Biol. 2008 Jun;28(12):4204-14.

The expanding RNA polymerase III transcriptome.

Dieci G, Fiorino G, Castelnuovo M, Teichmann M, Pagano A.

Trends Genet. 2007 Dec;23(12):614-22.

Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC.

Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M.

J Biol Chem. 2007 Jun 8;282(23):17179-89.

Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2.

Mertens C, Hofmann I, Wang Z, Teichmann M, Sepehri Chong S, Schnölzer M, Franke WW.

Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7795-800.

Spermiogenesis deficiency in mice lacking the Trf2 gene.

Zhang D, Penttila TL, Morris PL, Teichmann M, Roeder RG.

Science. 2001 May 11;292(5519):1153-5.

A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements.

Teichmann M, Wang Z, Roeder RG.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14200-5.

Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells.

Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG.

Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13720-5.


Functional interchangeability of TFIIIB components from yeast and human cells in vitro.

Teichmann M, Dieci G, Huet J, Rüth J, Sentenac A, Seifart KH.

EMBO J. 1997 Aug 1;16(15):4708-16.

Physical separation of two different forms of human TFIIIB active in the transcription of the U6 or the VAI gene in vitro.

Teichmann M, Seifart KH.

EMBO J. 1995 Dec 1;14(23):5974-83.

University of Bordeaux
Inserm U1212 - CNRS UMR 5320
146, rue Léo Saignat
Bâtiment 3A, 1st floor
33076 Bordeaux
Funding bodies
Ligue contre le Cancer:
                      - "équipe labellisée" from 2011 to 2015
logo ligue nationale.jpg


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