Contact the laboratory
Transcription and Tumor Laboratory
Lab Members
Martin Teichmann
Professor
Director of the Doctoral School of
Life Sciences and Health
email:
phone: ++33-5-5757-4647
Hélène Dumay-Odelot
Associate Professor
email:
phone: ++33-5-5757-5691
Francis Sagliocco
Associate Professor
Coordinator of the Master of Cellular and Molecular Genetics
email:
phone: ++33-5-5757-9504
Angélique Alonso-Marrau
Technician
email:
phone: ++33-5-5757-9504
Elisabeth Lata
PhD student
email:
phone: ++33-5-5757-9504


Research
We are interested in dissecting mechanisms that are altered in transcription regulation by human RNA polymerase (Pol) III during the process of tumoral transformation and in stem cells. For that purpose, we employ genetically defined human cellular model systems. We are in addition interested in determining the roles of Pol III in the development of leukodystrophies.
Recherche
Nous nous intéressons à la dissection des mécanismes altérés dans la régulation de la transcription par l'ARN polymérase (Pol) III humaine au cours du processus de transformation tumorale et dans les cellules souches. À cette fin, nous utilisons des systèmes modèles cellulaires avec des fonds génétiques bien définis. Nous sommes également intéressés à déterminer les rôles de la Pol III dans le développement des leucodystrophies.
Teaching
Our Team members are participating in teaching modules of the bachelor degree and of the Masters of Genetics (GMC), Cellular Biology (BCPP), Cancer Biology and Biochemistry of the University of Bordeaux.
For more detailed information, please contact the laboratory.
Enseignement
Les membres de notre équipe participent aux modules d’enseignement de la Licence et des Master de l’Université de Bordeaux en génétique (GMC), en biologie cellulaire (BCPP), en biologie du cancer et en biochimie.
Pour plus d'informations, veuillez contacter le laboratoire.
Selected Publications
Ferrari R, de Llobet Cucalon LI, Di Vona C, Le Dilly F, Vidal E, Lioutas A, Oliete JQ, Jochem L, Cutts E, Dieci G, Vannini A, Teichmann M, de la Luna S, Beato M.
The hRPC62 subunit of human RNA polymerase III displays helicase activity.
El Ayoubi L, Dumay-Odelot H, Chernev A, Boissier F, Minvielle-Sébastia L, Urlaub H, Fribourg S, Teichmann M.
Nucleic Acids Res. 2019 Sep 16. pii: gkz788. doi: 10.1093/nar/gkz788.
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz788/5569986?searchresult=1
Fusion-mediated genomic instability promotes aneuploidy patterns that resemble human tumors.
Delespaul, L, Merle , C, Lesluyes, T, Lagarde, P, Le Guellec, S, Pérot, G, Baud, J, Prochazkova-Carlotti, M, Danet, C, Fèvre, M, Rousseau, B, Durrieu-Gaillard, S, Teichmann, M, Coindre, JM, Lartigue, L, Chibon, F. Oncogene. 2019 Jul 3. doi: 10.1038/s41388-019-0859-6. [Epub ahead of print]
Karine Choquet, K, Forget, D, Meloche, E, Dicaire, MJ, Bernard, G, Vanderver, A, Schiffmann, R, Fabian, M, Teichmann, M, Coulombe, B, Brais, B, and Kleinman, C. J Biol Chem. 2019 May 3;294(18):7445-7459. doi: 10.1074/jbc.RA118.006271.
http://www.jbc.org/content/early/2019/03/21/jbc.RA118.006271
CRISPR/Cas9 genome editing induces megabase-scale chromosomal truncations.
Cullot, G, Boutin, J, Toutain, J, Prat, F, Pennamen, P, Rooryck, C, Teichmann, M, Rousseau, E, Lamrissi-Garcia, I, Guyonnet-Duperat, V, Bibeyran, A, Lalanne, M, Prouzet-Mauléon, V, Turcq, B, Ged, C, Blouin, JM, Richard, E, Dabernat, S, Moreau-Gaudry, F, Bedel, A.
Nat Commun. 2019 Mar 8;10(1):1136. doi: 10.1038/s41467-019-09006-2.
https://doi.org/10.1038/s41467-019-09006-2
Effects on prostate cancer cells of targeting RNA polymerase III.
Petrie1, JL, Swan, C, Ingram, RM, Frame, FM, Collins, AT, Dumay-Odelot, H, Teichmann, M, Maitland, NJ, White, RJ.
Nucleic Acids Res. 2019 May 7;47(8):3937-3956. doi: 10.1093/nar/gkz128.
https://doi.org/10.1093/nar/gkz128
Mutation in POLR3K causes hypomyelinating leukodystrophy and abnormal ribosomal RNA regulation.
Dorboz I, Dumay-Odelot H, Boussaid K, Bouyacoub Y, Barreau P, Samaan S, Jmel H, Eymard-Pierre E, Cances C, Bar C, Poulat AL, Rousselle C, Renaldo F, Elmaleh-Bergès M, Teichmann M, Boespflug-Tanguy O.
Neurol Genet. 2018 Dec 3;4(6):e289.
https://doi.org/10.1212/NXG.0000000000000289
Durrieu-Gaillard S, Dumay-Odelot H, Boldina G, Tourasse NJ, Allard D, André F, Macari F, Choquet A, Lagarde P, Drutel G, Leste-Lasserre T, Petitet M, Lesluyes T, Lartigue-Faustin L, Dupuy JW, Chibon F, Roeder RG, Joubert D, Vagner S, Teichmann M.
Cell Cycle. 2018;17(5):605-615.
https://doi.org/10.1080/15384101.2017.1405881
Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B.
Mol Brain. 2017 Apr 13;10(1):13.
https://doi.org/10.1186/s13041-017-0294-y
Macari F, El-Houfi Y, Boldina G, Xu H, Khoury-Hanna S, Ollier J, Yazdani L, Zheng G, Bièche I, Legrand N, Paulet D, Durrieu S, Byström A, Delbecq S, Lapeyre B, Bauchet L, Pannequin J, Hollande F, Pan T, Teichmann M, Vagner S, David A, Choquet A, Joubert D.
Oncogene. 2016 Apr 7;35(14):1785-96.
https://doi.org/10.1038/onc.2015.244
Structural analysis of human RPC32β-RPC62 complex.
Boissier F, Dumay-Odelot H, Teichmann M, Fribourg S.
J Struct Biol. 2015 Dec;192(3):313-319.
https://doi.org/10.1016/j.jsb.2015.09.004
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.
Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wüstefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E, Eilers M.
Nature. 2014 Jul 24;511(7510):483-7.
https://doi.org/10.1038/nature13473
Dumay-Odelot H, Durrieu-Gaillard S, El Ayoubi L, Parrot C, Teichmann M.
Transcription. 2014;5(1):e27526.
https://doi.org/10.4161/trns.27526
Pascali C, Teichmann M.
Subcell Biochem. 2013;61:261-87.
https://doi.org/10.1007/978-94-007-4525-4_12
Tétreault M, Choquet K, Orcesi S, Tonduti D, Balottin U, Teichmann M, Fribourg S, Schiffmann R, Brais B, Vanderver A, Bernard G.
Am J Hum Genet. 2011 Nov 11;89(5):652-5.
https://doi.org/10.1016/j.ajhg.2011.10.006
Bernard G, Chouery E, Putorti ML, Tétreault M, Takanohashi A, Carosso G, Clément I, Boespflug-Tanguy O, Rodriguez D, Delague V, Abou Ghoch J, Jalkh N, Dorboz I, Fribourg S, Teichmann M, Megarbane A, Schiffmann R, Vanderver A, Brais B.
Am J Hum Genet. 2011 Sep 9;89(3):415-23.
https://doi.org/10.1016/j.ajhg.2011.07.014
Widespread occurrence of non-canonical transcription termination by human RNA polymerase III.
Orioli A, Pascali C, Quartararo J, Diebel KW, Praz V, Romascano D, Percudani R, van Dyk LF, Hernandez N, Teichmann M, Dieci G.
Nucleic Acids Res. 2011 Jul;39(13):5499-512.
https://doi.org/10.1093/nar/gkr074
Lefèvre S, Dumay-Odelot H, El-Ayoubi L, Budd A, Legrand P, Pinaud N, Teichmann M, Fribourg S.
Nat Struct Mol Biol. 2011 Mar;18(3):352-8.
https://doi.org/10.1038/nsmb.1996
Teichmann M, Dieci G, Pascali C, Boldina G.
Transcription. 2010 Nov;1(3):130-135.
Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription.
Dumay-Odelot H, Durrieu-Gaillard S, Da Silva D, Roeder RG, Teichmann M.
Cell Cycle. 2010 Sep 15;9(18):3687-99.
Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.
Haurie V, Durrieu-Gaillard S, Dumay-Odelot H, Da Silva D, Rey C, Prochazkova M, Roeder RG, Besser D, Teichmann M.
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4176-81. https://doi.org/10.1073/pnas.0914980107
PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.
Woiwode A, Johnson SA, Zhong S, Zhang C, Roeder RG, Teichmann M, Johnson DL.
Mol Cell Biol. 2008 Jun;28(12):4204-14.
https://doi.org/10.1128/MCB.01912-07
The expanding RNA polymerase III transcriptome.
Dieci G, Fiorino G, Castelnuovo M, Teichmann M, Pagano A.
Trends Genet. 2007 Dec;23(12):614-22.
https://www.ncbi.nlm.nih.gov/pubmed/17977614
Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M.
J Biol Chem. 2007 Jun 8;282(23):17179-89.
http://www.jbc.org/content/282/23/17179.full
Mertens C, Hofmann I, Wang Z, Teichmann M, Sepehri Chong S, Schnölzer M, Franke WW.
Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7795-800.
Spermiogenesis deficiency in mice lacking the Trf2 gene.
Zhang D, Penttila TL, Morris PL, Teichmann M, Roeder RG.
Science. 2001 May 11;292(5519):1153-5.
https://www.ncbi.nlm.nih.gov/pubmed/11352070
Teichmann M, Wang Z, Roeder RG.
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14200-5.
https://www.pnas.org/content/97/26/14200.long
Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells.
Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG.
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13720-5.
https://www.pnas.org/content/96/24/13720
Functional interchangeability of TFIIIB components from yeast and human cells in vitro.
Teichmann M, Dieci G, Huet J, Rüth J, Sentenac A, Seifart KH.
EMBO J. 1997 Aug 1;16(15):4708-16.
http://emboj.embopress.org/content/16/15/4708
Teichmann M, Seifart KH.
EMBO J. 1995 Dec 1;14(23):5974-83.
https://www.embopress.org/doi/pdf/10.1002/j.1460-2075.1995.tb00286.x
Address
University of Bordeaux
Inserm U1212 - CNRS UMR 5320
146, rue Léo Saignat
Bâtiment 3A, 1st floor
33076 Bordeaux
FRANCE
Funding bodies
Ligue contre le Cancer:
- "équipe labellisée" from 2011 to 2015
INCa:
ANR:
ARC:
ODYSSEA:

